Blood-phosphatases
نویسندگان
چکیده
منابع مشابه
Protein Phosphatases Targeted Library
Preamble Phosphatases constitute a wide class of enzymes which remove a phosphate group from the target substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group. This action is directly opposite to that of phosphorylases and kinases. While kinases phosphorylate cellular substrates by using energetic molecules like ATP, phosphatases, in t...
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Enzyme-catalysed reversible protein phosphorylation is an important cellular regulatory mechanism (Nimmo & Cohen, 1977; Krebs & Beavo, 1979). Regulatory protein phosphorylation occurs most frequently on seryl and threonyl residues (Taborsky, 1974), and less frequently, on tyrosyl residues (Hunter, 1982). Protein phosphotyrosine [Tyr(P)] normally accounts for only 0.01-0.050o of the total protei...
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ence of two aberrant histopathological structures: the senile plaques and the neurofibrillary tangles. In the decade of the 1980s it was described that A peptide is the major component of senile plaques [1]. Also, in the same decade, the pioneer works of GrundkeIqbal et al. described the presence of tau [2], in hyperphosphorylated form [3], in the neurofibrillary tangles. Thus, two main feature...
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Because the liver carries out such a large number of important syntheses, it seems very.desirable to study the synthetic processes of this organ in vitro. However, there is considerable uncertainty in such studies because of the “notorious liver phosphatases,” which presumably could interfere with syntheses by breaking down ATP’ or any phosphorylated intermediates. In order to ascertain, if pos...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1931
ISSN: 0306-3283
DOI: 10.1042/bj0251724